Considering all mentioned ultrastructural morphological changes, we certainly can affirm, that the use of Nucleo CMF Forte affects favorably preservation and restoration of nerve structures, and promotes its quick and complete recovery after injury. The obtained results show a significant positive clinical efficiency of the remedy, containing nucleotides. Symptoms of thermal heat and cold hyperalgesia, dynamic and static components of mechanical hyperalgesia completely disappeared. Pain sensitivity excitation area was 2.96☐.31 cm2, 2.63 times less than the same in the comparison group (р<0.05). Tactile sensitivity excitation were 0.84☐.36 points, 3.2 times less than the comparison group (р<0.05). NTSS – 9 scale indicators were 2.,53☐.50 points, 5.77 times less than the comparison group (р<0.05). A spontaneous pain indicators 0.22☐.42 points, 6.72 times less than the comparison group (р<0.05). Clinical research has shown following results. In distal section of sciatic nerve ultrastructural signs were found, indicating the increased intracellular regeneration. Along with single myelin fibers with destruction signs, fibers with minor changes were located, as well as similar ones in intact rats. Nerve roots swelling, as well as nerve fibers degeneration also were less pronounced. After Nucleo CMF Forte treatment, both in proximal section, and in clamping place, and in distal section of sciatic nerve ultrastructural changes were less pronounced, comparing with rats, not being treated after sciatic nerve compression. In other nerve fibers, myelin sheath characterized by randomly oriented filamentary formations, which were divided by low electron density areas. Myelin sheath was homogeneous and structureless in some nerve fibers. Significant destructive changes were found in myelin sheath. Ultrastructural research revealed significant degenerative and destructive changes in axial cylinders axoplasm after proximal section clamping, clamping place and distal section of sciatic nerve. The study of subjective (spontaneous pain parameters, NTSS – 9 scale), objective (tactile sensitivity excitation degree, pain sensitivity excitation area, symptoms of thermal heat and cold hyperalgesia, dynamic and static components of mechanical hyperalgesia), and instrumental study (sensitivity threshold value, pain threshold, pain tolerance level) was carried out. Clinical efficiency of Nucleo CMF Forte was studied. Then, animal control, treatment using Nucleo CMF Forte within 10 days, and collection of material for histological study at the end of research were carried out. Surgery with nerve mobilization, and nerve compression by Pean forceps for 5 minutes were carried out. The object of our research was: morphological ultrastructural changes in nerves after nerve injury experimental modeling clinical signs of inferior alveolar nerve trauma in cases of mandible fractures.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |